Ammonia methanol dichloromethane → HCID 57845728, compound

HRID 735042Notes

Reaction equation

HRID 735042 reaction equation
Br[CH:2]([CH:19](Br)[C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)=[CH:22][CH:21]=1)[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:8][CH:7]=1)=[O:4].ClCCl.CO.N>>[N:13]1([CH2:12][C:9]2[CH:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[C:2]#[C:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=4)=[CH:22][CH:21]=3)=[CH:11][CH:10]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 21584172Ammonia methanol dichloromethaneHCID 68817360HCID 68817360, compound

Product 1

HCID 57845728HCID 57845728, compound

Procedure

Prepared analogously to Example 3.4.b. from 2.3-dibromo-3-(4′-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)propionamide. Yield: 26 mg (23.9% of theory); C27H25ClN2O (M=428.96); calc.: molecular ion peak (M+H)+: 429/431; found: molecular ion peak (M+H)+: 429/431; Rf value: 0.42 (silica gel, dichloromethane/methanol/ammonia (90:10:1)).

Workup

  1. customPrepared analogously to Example 3.4.b

Sources & evidence

ORD record
ord-7ff5a2da50294a7c9eddf2db90a77492
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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