HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → 3-(4'-Chlorobiphenyl-4-yl)propynoic acid(3-chloro-4-piperidin-1-ylmethylphenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 3-Chloro-4-piperidin-1-ylmethylphenylamine | HCID 28721833 | — |
| Reactant | (4'-Chlorobiphenyl-4-yl)propynoic acid | HCID 68816492 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(4'-Chlorobiphenyl-4-yl)propynoic acid(3-chloro-4-piperidin-1-ylmethylphenyl)amide | HCID 57845837 | — |
Reaction Steps
Prepared analogously to Example 3.7.c. from (4′-chlorobiphenyl-4-yl)propynoic acid and 3-chloro-4-piperidin-1-ylmethylphenylamine. Yield: 0.1 g (22% of theory); melting point: 277° C.-281° C.; C27H24Cl2N2 0 (M=463.4); calc.: molecular ion peak (M+H)+: 463/5/7 (Cl2); found: molecular ion peak (M+H)+: 463/5/7 (Cl2); Rf value: 0.50 (silica gel, dichloromethane/methanol (90:10)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-9cd4657ebc2a414b9371ca421879bdf5 |
| Source note | uspto-grants-2009_09 |