HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Piperidin-1-ylmethyl)aniline → 3-[5-(4-Chlorophenyl)pyridin-2-yl]propynoic acid-(4-piperidin-1-ylmethylphenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Piperidin-1-ylmethyl)aniline | HCID 846150 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | [5-(4-chlorophenyl)pyridin-2-yl]propynoic Acid | HCID 68816808 | — |
| Product | 3-[5-(4-Chlorophenyl)pyridin-2-yl]propynoic acid-(4-piperidin-1-ylmethylphenyl)amide | HCID 57845733 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from [5-(4-chlorophenyl)pyridin-2-yl]propynoic acid and 4-piperidin-1-ylmethylphenylamine. Yield: 0.2 g (48% of theory); C26H24ClN3O (M=429.95); calc.: molecular ion peak (M+H)+: 430/432; found: molecular ion peak (M+H)+: 430/432; Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (90:10:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-50c0ba4403af49afa7380d202aae99ee |
| Source note | uspto-grants-2009_09 |