HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Piperidin-1-ylmethyl)aniline → 3-(3-chlorobiphenyl-4-yl)propynoic acid-(4-piperidin-1-ylmethylphenyl)amide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Piperidin-1-ylmethyl)aniline | HCID 846150 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | (3-chlorobiphenyl-4-yl)propynoic Acid | HCID 68818528 | — |
| Product | 3-(3-chlorobiphenyl-4-yl)propynoic acid-(4-piperidin-1-ylmethylphenyl)amide Hydrochloride | HCID 68818415 | — |
Reaction Steps
Prepared analogously to Example 3.8 from (3-chlorobiphenyl-4-yl)propynoic acid and 4-piperidin-1-ylmethylphenylamine. Yield: 0.35 g (75% of theory); melting point: 260° C.-265° C.; C27H25ClN20*HCl (M=465.41); calc.: molecular ion peak (M+H)+: 429/31 (Cl); found: molecular ion peak (M+H)+: 429/31 (Cl); Rf value: 0.6 (silica gel, dichloromethane/methanol/ammonia (90:10:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-d3b5aeaa5b6a4f9c8e3fff2998e3e4ba |
| Source note | uspto-grants-2009_09 |