4-(diethylaminomethyl)aniline → HCID 57845846, compound

HRID 735069Notes

Reaction equation

HRID 735069 reaction equation
[CH2:1]([N:3]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1)[CH2:4][CH3:5])[CH3:2].[Cl:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1[C:25]#[C:26][C:27](O)=[O:28]>ClCCl.CO>[CH2:1]([N:3]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:27](=[O:28])[C:26]#[C:25][C:16]2[CH:17]=[CH:18][C:19]([C:21]([F:23])([F:22])[F:24])=[CH:20][C:15]=2[Cl:14])=[CH:11][CH:12]=1)[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 2368034-(diethylaminomethyl)anilineHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

Product 1

HCID 57845846HCID 57845846, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 2.3.f. from 4-diethylaminomethylphenylamine and (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 72 mg (59% of theory); C21H20ClF3N2O (M=408.85); calc.: molecular ion peak (M+H)+: 409/411; found: molecular ion peak (M+H)+: 409/411; Rf value: 0.35 (silica gel, dichloromethane/methanol (9:1)).

Workup

  1. customPrepared analogously to Example 2.3.f

Sources & evidence

ORD record
ord-98669d61f45e45bab239d74510b45566
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

Loading…