4-(Piperidin-1-ylmethyl)aniline → HCID 68816185, compound

HRID 735070Notes

Reaction equation

HRID 735070 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:17]=1[C:26]#[C:27][C:28](O)=[O:29]>ClCCl.CO>[ClH:15].[N:1]1([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:28](=[O:29])[C:27]#[C:26][C:17]3[CH:18]=[CH:19][C:20]([C:22]([F:24])([F:23])[F:25])=[CH:21][C:16]=3[Cl:15])=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8461504-(Piperidin-1-ylmethyl)anilineHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

Product 1

HCID 68816185HCID 68816185, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 2.3.f. from 4-piperidin-1-ylmethylphenylamine and (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 170 mg (40% of theory); C22H20ClF3N2O (M=420.86); melting point: 193° C.-195° C.; calc.: molecular ion peak (M−H)−: 419/421(Cl); found: molecular ion peak (M−H)−: 419/421 (Cl); Rf value: 0.5 (silica gel, dichloromethane/methanol (9:1)).

Workup

  1. customPrepared analogously to Example 2.3.f

Sources & evidence

ORD record
ord-2a29295512b649c9af001cffe55e5e63
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

Loading…