HCID 62677566, compound → HCID 57845838, compound

HRID 735072Notes

Reaction equation

HRID 735072 reaction equation
[N:1]1[N:2]=[CH:3][N:4]([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH:5]=1.[Cl:16][C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1[C:27]#[C:28][C:29](O)=[O:30]>ClCCl.CO>[N:1]1[N:2]=[CH:3][N:4]([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:29](=[O:30])[C:28]#[C:27][C:18]3[CH:19]=[CH:20][C:21]([C:23]([F:25])([F:24])[F:26])=[CH:22][C:17]=3[Cl:16])=[CH:11][CH:10]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 62677566HCID 62677566, compoundHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

Product 1

HCID 57845838HCID 57845838, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 2.3.f. from 4-(2-[1.2.4]triazol-4-ylethoxy)phenylamine and (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 51 mg (39.4% of theory); melting point: 223° C.-227° C.; C20H14ClF3N4O2 (M=434.80); calc.: molecular ion peak (M+H)+: 435/437; found: molecular ion peak (M+H)+: 435/437; Rf value: 0.31 (silica gel, dichloromethane/methanol (9:1)).

Workup

  1. customPrepared analogously to Example 2.3.f

Sources & evidence

ORD record
ord-53f21d52b2714e43b8143034b527166c
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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