反应详情

Prepared analogously to Example 2.3.f. from [5-(4-chlorophenyl)pyridin-2-yl]propynoic acid and 4-[4-(tert-butyldimethylsilanyloxy)piperidin-1-ylmethyl]phenylamine. The cleaving of the silyl group is carried out by adding tetrabutylammonium fluoride to a solution of the silylether in THF. Yield: 0.25 g (43% of theory); melting point: 186° C.-190° C.; C26H24ClN3O2 (M=445.94); calc.: molecular ion peak (M+H)+: 446/448; found: molecular ion peak (M+H)+: 446/448; Rf value: 0.6 (silica gel, dichloromethane/methanol/ammonia (90:10:0.1)).

1. customPrepared analogously to Example 2.3.f