HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(2-diethylaminoethoxy)phenylamine → 3-pyridin-2-ylpropynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(2-diethylaminoethoxy)phenylamine | HCID 16791676 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | 3-(Pyridin-2-yl)propiolic acid | HCID 45489877 | — |
| Product | 3-pyridin-2-ylpropynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride | HCID 68819501 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from pyridin-2-ylpropynoic acid and [2-(2-chloro-4-aminophenoxy)ethyl]diethylamine. Yield: 0.37 g (53.3% of theory); C20H22ClN3O2*HCl (M=408.33); calc.: molecular ion peak (M+H)+: 372/374; found: molecular ion peak (M+H)+: 372/374; Rf value: 0.5 (silica gel, dichloromethane/methanol/ammonia (9:1:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-08012dac568a43ab93b470d47a47e5d8 |
| Source note | uspto-grants-2009_09 |