HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,4-dichlorophenyl)prop-2-ynoic acid → 3-(2,4-Dichlorophenyl)propynoic acid-[2-(2-pyrrolidin-1-ylethyl)benzoxazol-5-yl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,4-dichlorophenyl)prop-2-ynoic acid | HCID 228509 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | 5-Amino-2-(2-pyrrolidin-1-ylethyl)benzoxazole | HCID 68817945 | — |
| Product | 3-(2,4-Dichlorophenyl)propynoic acid-[2-(2-pyrrolidin-1-ylethyl)benzoxazol-5-yl]amide | HCID 57845745 | — |
Reaction Steps
Prepared analogously to Example 3.1.e. from 5-amino-2-(2-pyrrolidin-1-ylethyl)benzoxazole and (2,4-dichlorophenyl)propynoic acid. Yield: 43 mg (33.1% of theory); C22H19Cl2N3O2 (M=428.32); melting point: 130° C.; calc.: molecular ion peak (M+H)+: 428/430/432; found: molecular ion peak (M+H)+: 428/430/432; C13H17N3O (M=231.30); calc.: molecular ion peak (M+H)+: 232; found: molecular ion peak (M+H)+: 232; Rf value: 0.21 (silica gel, dichloromethane/methanol/ammonia (10:1:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-7ad0d630371542c2999960ab71f53ac4 |
| Source note | uspto-grants-2009_09 |