Ammonia methanol dichloromethane → Ethyl 5-amino-2-[2-(diethylamino)ethoxy]benzoate

HRID 735103노트

반응식

HRID 735103 반응식
[CH2:1]([N:3]([CH2:21][CH3:22])[CH2:4][CH2:5][O:6][C:7]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH3:2].ClCCl.CO.N>C(OCC)(=O)C>[NH2:18][C:15]1[CH:16]=[CH:17][C:7]([O:6][CH2:5][CH2:4][N:3]([CH2:21][CH3:22])[CH2:1][CH3:2])=[C:8]([CH:14]=1)[C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

4

반응물 2

HCID 21584172Ammonia methanol dichloromethaneHCID 57632929Ethyl 2-(2-diethylaminoethoxy)-5-nitrobenzoate

생성물 1

HCID 57632512Ethyl 5-amino-2-[2-(diethylamino)ethoxy]benzoate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Prepared analogously to Example 3.1.b. from 0.30 g ethyl 2-(2-diethylaminoethoxy)-5-nitrobenzoate in ethyl acetate. Yield: 0.27 g (100% of theory); C15H24N2O3 (M=280.37); calc.: molecular ion peak (M+H)+: 281; found: molecular ion peak (M+H)+: 281; Rf value: 0.40 (silica gel, dichloromethane/methanol/ammonia (39:1:0.1)).

후처리

  1. customPrepared analogously to Example 3.1.b

출처 및 근거

ORD 기록
ord-631e434f480f4e568b68718c39541a1a
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592373B2

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