反应详情

A solution of 1.85 g (6.26 mmol) of N-[4-(2-diethylaminoethoxy)-3-nitrophenyl]acetamide in semiconcentrated aqueous hydrochloric acid is stirred for 2 hours at 100° C., cooled to ambient temperature, made basic with ice, and concentrated aqueous ammonia and the aqueous phase is exhaustively extracted with ethyl acetate. The combined organic phases are washed with water and dried over sodium sulfate. Yield: 1.38 g (87% of theory); C12H19N3O3 (M=253.30); calc.: molecular ion peak (M+H)+: 254; found: molecular ion peak (M+H)+: 254; Rf value: 0.68 (Alox, dichloromethane/methanol (39:1)).

1. extractionthe aqueous phase is exhaustively extracted with ethyl acetate
2. washThe combined organic phases are washed with water
3. dry with materialdried over sodium sulfate