反应详情

A reaction mixture of 7.8 g (27.81 mmol) of 1-(2-bromoethoxy)-2-chloro-4-nitrobenzene and 10.14 mL (84 mmol) of 4-methylpiperidine in 100 mL of dichloromethane is stirred for 18 hours at ambient temperature. Then the solution is purified by column chromatography on 400 g of Alox act. II-III (eluant: dichloromethane/methanol (49:1)). Yield: 6.9 g (83% of theory); C14H19ClN2O3 (M=298.77); calc.: molecular ion peak (M+H)+: 209/301; found: molecular ion peak (M+H)+: 209/301; Rf value: 0.48 (Alox, petroleum ether/ethyl acetate (3:1)).

1. customThen the solution is purified by column chromatography on 400 g of Alox act