HCID 68818181, compound → 3-Chloro-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylamine

HRID 735114Notes

Reaction equation

HRID 735114 reaction equation
[Cl:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][CH:10]([CH3:13])[CH2:9][CH2:8]1>ClCCl.CO>[Cl:1][C:2]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][CH2:6][N:7]1[CH2:8][CH2:9][CH:10]([CH3:13])[CH2:11][CH2:12]1

Participants

3

Reactant 1

HCID 68818181HCID 68818181, compound

Product 1

HCID 578921123-Chloro-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylamine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 3.1.b. from 1-[2-(2-chloro-4-nitrophenoxy)ethyl]4-methylpiperidine. Yield: 3.66 g (59% of theory); C14H21ClN2O (M=268.78); calc.: molecular ion peak (M+H)+: 269/271; found: molecular ion peak (M+H)+: 269/271; Rf value: 0.52 (silica gel, dichloromethane/methanol (9:1)).

Workup

  1. customPrepared analogously to Example 3.1.b

Sources & evidence

ORD record
ord-7f09f6da8bf646fd8beb1d10626e8be0
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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