HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine → 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-{3-chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenyl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine | HCID 59691670 | — |
| Reactant | (2-Chloro-4-trifluoromethylphenyl)propynoic acid | HCID 68817422 | — |
| Product | 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-{3-chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenyl}amide | HCID 57845787 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (2-chloro-4-trifluoromethylphenyl)propynoic acid and 3-chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine. Yield: 0.21 g (45.3% of theory); C24H23Cl2F3N2O (M=483.36); calc.: molecular ion peak (M+H)+: 483/485/487; found: molecular ion peak (M+H)+: 483/485/487; Rf value: 0.65 (Alox, petroleum ether/ethyl acetate (1:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-5cac578e1f044238b63d7193696b0ff5 |
| Source note | uspto-grants-2009_09 |