HCID 68816995, compound → HCID 68817874, compound

HRID 735127Notes

Reaction equation

HRID 735127 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]#[C:13][C:14]([OH:16])=O.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:31])[CH:21]=[CH:22][C:23]=1[CH2:24][CH2:25][NH:26][CH2:27][CH:28]1[CH2:30][CH2:29]1>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:31][C:14](=[O:16])[C:13]#[C:12][C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[Cl:1])[CH:21]=[CH:22][C:23]=1[CH2:24][CH2:25][NH:26][CH2:27][CH:28]1[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 68816995HCID 68816995, compoundHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

Product 1

HCID 68817874HCID 68817874, compound

Procedure

Prepared analogously to Example 2.3.f. from (2-chloro-4-trifluoromethylphenyl)propynoic acid and 3-chloro-4-[2-(cyclopropylmethylamino)ethyl]phenylamine. Yield: 15 mg (3.4% of theory); C22H19Cl2F3N2O (M=455.31); calc.: molecular ion peak (M+H)+: 455/457/459; found: molecular ion peak (M+H)+: 455/457/459; Rf value: 0.3 (Alox, petroleum ether/ethyl acetate (3:1)).

Workup

  1. customPrepared analogously to Example 2.3.f

Sources & evidence

ORD record
ord-3800944a4d1344709868d58623a5e55b
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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