HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-(2-Methoxy-4-nitrophenoxy)ethyl]-1,2,3,4-tetrahydroisoquinoline → 4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethoxy]-3-methoxyphenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-(2-Methoxy-4-nitrophenoxy)ethyl]-1,2,3,4-tetrahydroisoquinoline | HCID 68816329 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethoxy]-3-methoxyphenylamine | HCID 68817412 | — |
Reaction Steps
Prepared analogously to Example 3.1.b. from 1.4 g (2.77 mmol) of 2-[2-(2-methoxy-4-nitrophenoxy)ethyl]-1,2,3,4-tetrahydroisoquinoline (65%). Yield: 1.2 g (94% of theory); C18H22N2O2 (M=298.38); calc.: molecular ion peak (M+H)+: 299; found: molecular ion peak (M+H)+: 299; Rf value: 0.5 (silica gel, dichloromethane/methanol (9:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-6abb61bd40594f1da7d8b0815c8f9d00 |
| Source note | uspto-grants-2009_09 |