4-Piperidinecarboxamide → HCID 68818347, compound

HRID 735145Notes

Reaction equation

HRID 735145 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[O:14][CH3:15].[NH:16]1[CH2:21][CH2:20][CH:19]([C:22]([NH2:24])=[O:23])[CH2:18][CH2:17]1.ClCCl.CO.N>>[CH3:15][O:14][C:6]1[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=[CH:10][C:5]=1[O:4][CH2:3][CH2:2][N:16]1[CH2:21][CH2:20][CH:19]([C:22]([NH2:24])=[O:23])[CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 37724-PiperidinecarboxamideHCID 129372541-(2-Bromoethoxy)2-methoxy-4-nitrobenzeneHCID 21584172Ammonia methanol dichloromethane

Product 1

HCID 68818347HCID 68818347, compound

Procedure

Prepared analogously to Example 1.1.c. from 1 g (3.622 mmol) of 1-(2-bromoethoxy)-2-methoxy-4-nitrobenzene and 1.4 g (10.87 mmol) of piperidine-4-carboxylic acid amide. Yield: 1.05 g (90% of theory); C15H21N3O5 (M=323.34); calc.: molecular ion peak (M+H)+: 324; found: molecular ion peak (M+H)+: 324; Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (9:1:0.1)).

Workup

  1. customPrepared analogously to Example 1.1.c

Sources & evidence

ORD record
ord-c7e245ed313f4ce4ad52c78f2b07e0d9
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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