Ammonia methanol dichloromethane → HCID 68817417, compound

HRID 735146Notes

Reaction equation

HRID 735146 reaction equation
[CH3:1][O:2][C:3]1[CH:20]=[C:19]([N+:21]([O-])=O)[CH:18]=[CH:17][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1.ClCCl.CO.N>>[NH2:21][C:19]1[CH:18]=[CH:17][C:4]([O:5][CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]2)=[C:3]([O:2][CH3:1])[CH:20]=1

Participants

3

Reactant 2

HCID 21584172Ammonia methanol dichloromethaneHCID 68818347HCID 68818347, compound

Product 1

HCID 68817417HCID 68817417, compound

Procedure

Prepared analogously to Example 3.1.b. from 1 g (3.1 mmol) of 1-[2-(2-methoxy-4-nitrophenoxy)ethyl]piperidine-4-carboxylic acid amide. Yield: 0.8 g (88% of theory); C15H23N3O3 (M=298.38); calc.: molecular ion peak (M+H)+: 294; found: molecular ion peak (M+H)+: 294; Rf value: 0.3 (silica gel, dichloromethane/methanol/ammonia (9:1:0.1)).

Workup

  1. customPrepared analogously to Example 3.1.b

Sources & evidence

ORD record
ord-7463d4175f804b80b2b0c18ed619bca4
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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