HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(2-diethylaminoethyl)phenylamine → 3-(3-bromobiphenyl-4-yl)propynoic acid-[3-chloro-4-(2-diethylaminoethyl)phenyl]amide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(2-diethylaminoethyl)phenylamine | HCID 59691617 | — |
| Reactant | (3-bromobiphenyl-4-yl)propynoic Acid | HCID 68818231 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(3-bromobiphenyl-4-yl)propynoic acid-[3-chloro-4-(2-diethylaminoethyl)phenyl]amide Hydrochloride | HCID 68816503 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (3-bromobiphenyl-4-yl)propynoic acid and 3-chloro-4-(2-diethylaminoethyl)phenylamine. Yield: 95 mg (23.8% of theory); C27H26BrClN2O*HCl (M=546.32); calc.: molecular ion peak (M+H)+: 509/11/13; found: molecular ion peak (M+H)+: 509/11/13; Rf value: 0.3 (silica gel, dichloromethane/methanol (90:10)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-36ab13ac32b349d48362282541917b35 |
| Source note | uspto-grants-2009_09 |