rel-(3R,5S)-3,5-Dimethylpiperidine → (E)-N-(4'-chlorobiphenyl-4-yl)-3-[4-(cis-3,5-dimethylpiperidin-1-ylmethyl)phenyl]acrylamide

Participants

Role	Name	HCID	Charge
Reactant	rel-(3R,5S)-3,5-Dimethylpiperidine	HCID 641101	—
Reactant	(E)-N-(4'-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide	HCID 68816418	—
Product	(E)-N-(4'-chlorobiphenyl-4-yl)-3-[4-(cis-3,5-dimethylpiperidin-1-ylmethyl)phenyl]acrylamide	HCID 57845848	—

Reaction Steps

Prepared analogously to Example 1.2.c. from (E)-N-(4′-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide and cis-3,5-dimethylpiperidine. Yield: 30 mg (30% of theory); melting point: 217° C.-218° C.; C29H31ClN2O (M=459.03); calc.: molecular ion peak (M+H)+: 459/461; found: molecular ion peak (M+H)+: 459/461.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07592373B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-59c47cfa923747aba9de140bd5e6df9a
Source note	uspto-grants-2009_09