反应详情

A reaction mixture of 100 mg (0.26 mmol) of (E)-N-(4′-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide, 70 mg (0.77 mmol) of 2-methoxyethylmethylamine, and 140 mg (1 mmol) of potassium carbonate in 10 mL of acetone is agitated for 24 hours at reflux temperature. The reaction mixture is evaporated down. The residue is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia (20/1/0.1)). Yield: 92 mg (81% of theory); melting point: 222° C.-223° C.; C26H27ClN2O2 (M=434.96); calc.: molecular ion peak (M+H)+: 435/37(Cl); found: molecular ion peak (M+H)+: 435/37(Cl); Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (20:1:0.1)).

1. temperatureat reflux temperature
2. customThe reaction mixture is evaporated down
3. customThe residue is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia (20/1/0.1))