反应详情

A reaction mixture of 70 mg (0.18 mmol) of N-(4′-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)propionamide, 18 mg (0.15 mmol) of methylpyridin-4-ylmethylamine, and 41 mg (0.3 mmol) of potassium carbonate in 5 mL of acetone is agitated for 24 hours at reflux temperature. The reaction mixture is evaporated down. The residue is triturated with water and diisopropyl ether, suction filtered and dried in the air. Yield: 52 mg (87% of theory); melting point: 102° C.; C29H28ClN3O (M=470.01); calc.: molecular ion peak (M+H)+: 470/72 (Cl); found: molecular ion peak (M+H)+: 470/72 (Cl).

1. temperatureat reflux temperature
2. customThe reaction mixture is evaporated down
3. customThe residue is triturated with water and diisopropyl ether, suction
4. filtrationfiltered
5. customdried in the air