HCID 68816510, compound → HCID 57845843, compound

HRID 735190Notes

Reaction equation

HRID 735190 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]#[C:13][C:14]([OH:16])=O.[NH2:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[N:24]=[C:23](C1CCCCN1)[CH:22]=[CH:21]2>ClCCl.CO>[N:24]1([C:23]2[CH:22]=[CH:21][C:20]3[C:25](=[CH:26][CH:27]=[C:18]([NH:17][C:14](=[O:16])[C:13]#[C:12][C:3]4[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=4[Cl:1])[CH:19]=3)[N:24]=2)[CH2:25][CH2:20][CH2:21][CH2:22][CH2:23]1

Participants

4

Reactant 2

HCID 68816510HCID 68816510, compoundHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

Product 1

HCID 57845843HCID 57845843, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 2.3.f. from (2-chloro-4-trifluoromethylphenyl)propynoic acid and 6-amino-2-piperidin-2-ylquinoline. Yield: 170 mg (37.1% of theory); melting point: 176° C.-179° C.; C24H19ClF3N3O (M=457.88); calc.: molecular ion peak (M+H)+: 456/458; found: molecular ion peak (M+H)+: 456/458; Rf value: 0.62 (silica gel, dichloromethane/methanol (19:1)).

Workup

  1. customPrepared analogously to Example 2.3.f

Sources & evidence

ORD record
ord-85b759305ba24fb88124de2131ae1583
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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