Isopropyl(6-nitroquinolin-2-yl)amine → N2-Isopropylquinoline-2,6-diamine

HRID 735192Notes

Reaction equation

HRID 735192 reaction equation
[CH:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:15]([O-])=O)[CH:11]=2)[N:6]=1)([CH3:3])[CH3:2]>ClCCl.CO>[CH:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH2:15])[CH:11]=2)[N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 43450861Isopropyl(6-nitroquinolin-2-yl)amine

Product 1

HCID 43450828N2-Isopropylquinoline-2,6-diamine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 3.1.b. from isopropyl-(6-nitroquinolin-2-yl)amine. Yield: 0.51 g (78.1% of theory); C12H15N3 (M=201.27); calc.: molecular ion peak (M+H)+: 202; found: molecular ion peak (M+H)+: 202; Rf value: 0.25 (silica gel, dichloromethane/methanol (19:1)).

Workup

  1. customPrepared analogously to Example 3.1.b

Sources & evidence

ORD record
ord-0196d0acd1fd41d2b76949c9fa432a48
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

Loading…