Phenyl isocyanate → Phenylurea

HRID 735215Notes

Reaction equation

HRID 735215 reaction equation
C1(N=C=O)C=CC=CC=1.COC(=O)C1C=CC=CC=1NC(C1C2C(OC(C)(C)O2)C(N2C=NC3C2=NC=NC=3[NH:41][C:42]([NH:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)=[O:43])O1)=O>>[C:45]1([NH:44][C:42]([NH2:41])=[O:43])[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 67150791HCID 67150791, compound

Product 1

HCID 6145Phenylurea

Procedure

Phenyl isocyanate was coupled with the amide product using a method similar to those described above, affording the intermediate phenylurea compound. MW calculated for C30H29N7O7 (MH+) 600, found 600 by LCMS.

Sources & evidence

ORD record
ord-f0d29803a30d44308a130d2bc9cccf15
Source dataset
uspto-grants-2009_09
Patent number
US07592445B2

Reaction notes

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