Sodium 6-(4-fluorophenyl)naphthalene-2-sulfinate → HCID 87616591, compound

HRID 735356Notes

Reaction equation

HRID 735356 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1I)\[CH3:5].[F:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]3[C:27](=[CH:28][CH:29]=2)[CH:26]=[C:25]([S:30]([O-:32])=[O:31])[CH:24]=[CH:23]3)=[CH:16][CH:15]=1.[Na+]>>[CH3:1][O:2]/[N:3]=[C:4](/[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[S:30]([C:25]1[CH:24]=[CH:23][C:22]2[C:27](=[CH:28][CH:29]=[C:20]([C:17]3[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=3)[CH:21]=2)[CH:26]=1)(=[O:31])=[O:32])\[CH3:5]

Participants

3

Reactant 2

HCID 68900681Sodium 6-(4-fluorophenyl)naphthalene-2-sulfinateHCID 87616778HCID 87616778, compound

Product 1

HCID 87616591HCID 87616591, compound

Procedure

Prepared according to the method of Example 6, Step 4 using (1E)-1-(2-iodophenyl)ethanone O-methyloxime and sodium 6-(4-fluorophenyl)naphthalene-2-sulfinate. 1H NMR (400 MHz, d6-DMSO): δ 8.56 (1H, s), 8.35 (1H, s), 8.29-8.27 (2H, m), 8.17 (1H, d, J=8.8 Hz), 8.02 (1H, dd, J=1.7, 8.6 Hz), 7.91 (2H, dd, J=5.5, 8.8 Hz), 7.83-7.71 (3H, m), 7.44 (1H, dd, J=1.7, 7.4 Hz), 7.37 (2H, t, J=8.8 Hz), 3.56 (3H, s), 2.14 (3H, s); m/z (ES+) 434 [MH+].

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-17259cd2278c43fe9eced2ae1905a66a
Source dataset
uspto-grants-2009_09
Patent number
US07592456B2

Reaction notes

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