Sodium Hydroxide → HCID 10458247, compound

HRID 735384Notes

Reaction equation

HRID 735384 reaction equation
[CH3:1][C:2]1([CH3:33])[C:11]2[CH:10]=[C:9]([Se:12][C:13]#[C:14][C:15]3[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[C:17]([F:25])[CH:16]=3)[CH:8]=[CH:7][C:6]=2[C:5]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)=[CH:4][CH2:3]1.[OH-].[Na+]>>[CH3:1][C:2]1([CH3:33])[C:11]2[CH:10]=[C:9]([Se:12][C:13]#[C:14][C:15]3[CH:24]=[CH:23][C:18]([C:19]([OH:21])=[O:20])=[C:17]([F:25])[CH:16]=3)[CH:8]=[CH:7][C:6]=2[C:5]([C:26]2[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=2)=[CH:4][CH2:3]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86601149Methyl 4-[2-[[7,8-dihydro-8,8-dimethyl-5-(4-methylphenyl)-2-naphthalenyl]seleno]ethynyl]-2-fluorobenzoate

Product 1

HCID 10458247HCID 10458247, compound

Procedure

In a manner similar to that of Example 7d, by reacting 1.28 g (2.5 mmol) of methyl 4-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)-2-fluorobenzoate with 0.51 g (13 mmol) of sodium hydroxide, a yellow solid is obtained (0.77 g; yield=63%; m.p.=145° C.).

Workup

  1. customa yellow solid is obtained (0.77 g; yield=63%; m.p.=145° C.)

Sources & evidence

ORD record
ord-bdf0c8acb3d9432eb47da929020ce2cc
Source dataset
uspto-grants-2009_09
Patent number
US07592478B2

Reaction notes

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