Lithium hydroxide, monohydrate → HCID 10455863, compound

HRID 735393Notes

Reaction equation

HRID 735393 reaction equation
[CH3:1][C:2]1([CH3:34])[C:11]2[CH:10]=[C:9]([C:12](=[O:26])[C:13]([NH:15][C:16]3[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=3)=[O:14])[CH:8]=[CH:7][C:6]=2[C:5]([C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=2)=[CH:4][CH2:3]1.O.[OH-].[Li+]>>[CH3:1][C:2]1([CH3:34])[C:11]2[CH:10]=[C:9]([C:12](=[O:26])[C:13]([NH:15][C:16]3[CH:25]=[CH:24][C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=3)=[O:14])[CH:8]=[CH:7][C:6]=2[C:5]([C:27]2[CH:28]=[CH:29][C:30]([CH3:33])=[CH:31][CH:32]=2)=[CH:4][CH2:3]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 69071361HCID 69071361, compound

Product 1

HCID 10455863HCID 10455863, compound

Procedure

In a manner similar to that of Example 22e, by reacting 0.4 g (0.88 mmol) of methyl 4-[2-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthyl)-2-oxoacetylamino]benzoate with 0.074 g (1.77 mmol) of lithium hydroxide hydrate, a yellow solid is obtained (0.21 g; yield=56%; m.p.=255° C.).

Workup

  1. customa yellow solid is obtained (0.21 g; yield=56%; m.p.=255° C.)

Sources & evidence

ORD record
ord-bcbec7e2a3394d6394566c29226ec2e0
Source dataset
uspto-grants-2009_09
Patent number
US07592478B2

Reaction notes

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