Isopropyl iodide → HCID 67021072, compound

HRID 735414Notes

Reaction equation

HRID 735414 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19].[H-].[Na+].I[CH:23]([CH3:25])[CH3:24]>>[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=3[CH3:19])[N:8]([CH:23]([CH3:25])[CH3:24])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 178489140HCID 178489140, compound

Product 1

HCID 67021072HCID 67021072, compoundYield 36%

Procedure

Prepared according to Example 101 from 7-chloro-3-(4-methoxy-2-methylphenyl)-1H-indazole (0.150 g, 0.52 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and 2-iodopropane (0.07 mL, 0.7 mmol) to give the title compound (0.059 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f245fbe2725448c8ba39c2ac73ba9766
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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