Bromocyclopentane → 2-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-2H-indazole

HRID 735421Notes

Reaction equation

HRID 735421 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].[CH:21]1(Br)[CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([N:8]2[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[C:6]3[C:10]([C:2]([F:1])=[CH:3][CH:4]=[CH:5]3)=[N:9]2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 24758Sodium hydrideHCID 178489142HCID 178489142, compound

Product 1

HCID 115005622-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-2H-indazoleYield 5.7%

Procedure

Prepared according to Example 116 from 7-fluoro-3-(4-methoxyphenyl)-1H-indazole (0.75 g, 3.1 mmol), sodium hydride (60% in oil, 0.124 g, 3.1 mmol) and cyclopentylbromide (0.36 mL, 3.3 mmol) to give the title compound (0.055 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c206adf57ecb4e1a88490b03649dd4ef
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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