反应详情

A solution of methyl 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylate (0.100 g, 0.25 mmol) and lithium aluminum (0.1 g, 0.25 mmol) in 5 mL THF was stirred at ambient temperature for 1 hour. Excess hydride was decomposed by the addition of 0.1 mL H2O, 0.1 mL 1N NaOH, 0.3 mL H2O and 100 mg of Na2SO4. The solids were filtered and the filtrate concentrated in vacuo to give 0.09 g of product as a light yellow solid.

1. filtrationThe solids were filtered
2. concentrationthe filtrate concentrated in vacuo