HCID 11663947, compound → HCID 11627513, compound

HRID 735445Notes

Reaction equation

HRID 735445 reaction equation
[F:1][C:2]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([F:39])[C:3]=1[CH2:4][N:5]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:29][CH2:28][C:23]4(OCC[O:24]4)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=[C:12]2[C:7]([C:8]([C:30]([F:33])([F:32])[F:31])=[CH:9][CH:10]=[CH:11]2)=[N:6]1>C(O)=O>[F:1][C:2]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([F:39])[C:3]=1[CH2:4][N:5]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:21][CH2:22][C:23](=[O:24])[CH2:28][CH2:29]3)=[CH:16][CH:15]=2)=[C:12]2[C:7]([C:8]([C:30]([F:33])([F:31])[F:32])=[CH:9][CH:10]=[CH:11]2)=[N:6]1

Participants

3

Reactant 1

HCID 11663947HCID 11663947, compound

Product 1

HCID 11627513HCID 11627513, compoundYield 55.2%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 8-{4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}-1,4-dioxa-8-azaspiro[4.5]decane (0.195 g, 0.36 mmol) in 2 mL of formic acid was heated at 70° C. for 2 hours. The solvent was evaporated and the residue purified by flash chromatography (CH2Cl2-EtOAc, 19:1) to give 0.1 g of the title compound.

Workup

  1. customThe solvent was evaporated
  2. customthe residue purified by flash chromatography (CH2Cl2-EtOAc, 19:1)

Sources & evidence

ORD record
ord-0cff62c784f14457a65252643c9881bf
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

Loading…