Morpholine → N-(3-iodophenyl)morpholine-4-carboxamide

HRID 735454Notes

Reaction equation

HRID 735454 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>O1CCOCC1>[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 44990001-Iodo-3-isocyanatobenzene

Product 1

HCID 34669033N-(3-iodophenyl)morpholine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-iodophenylisocyanate (0.1 g, 0.41 mmol) and morpholine (0.04 mL, 0.45 mmol) in 2 mL dioxane were heated at 100° C. overnight. The solvent was evaporated and the resulting product was used without purification.

Workup

  1. customThe solvent was evaporated
  2. customthe resulting product was used without purification

Sources & evidence

ORD record
ord-2ac11e4619694d1fb29660e57b04f049
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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