反应详情

Then a solution of 3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole (0.183 g, 0.7 mmol) and 2,4,6-trifluorobenzyl bromide (0.203 g, 0.9 mmol) in DMF (5 mL) was heated at 120° C. After 5 days, the reaction mixture was partitioned with EtOAc and water. Organics were washed with water (3×), then brine and dried over MgSO4, then stripped and the resulting crude product was flashed by reverse phase HPLC to afford the title compound (0.033 g, 5%).

1. customthe reaction mixture was partitioned with EtOAc and water
2. washOrganics were washed with water (3×)
3. dry with materialbrine and dried over MgSO4