HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(neopentyl glycolato)diboron → N-(3-Cyano-4-(ethylsulfonyl)phenyl)-4-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-methylphenyl)butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(neopentyl glycolato)diboron | HCID 2734316 | — |
| Reactant | 4-(4-Bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide | HCID 57842660 | — |
| Reactant | 4-[4-(5,5-Dimethyl-[1,3,2]dioxaborinan-2-yl)-phenyl]-butyric acid | HCID 57842777 | — |
| Product | N-(3-Cyano-4-(ethylsulfonyl)phenyl)-4-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-methylphenyl)butanamide | HCID 57842912 | 88% |
Reaction Steps
Using a procedure analogous to that used to prepare 2A, 8B (448 mg, 1.00 mmol) was reacted with 5,5,5′,5′-Tetramethyl-[2,2′]bi[[1,3,2]dioxaborinanyl] to afford 8C (425 mg, 88%) as an off-white solid. MS (ESI) m/z 413.1 (M−H)− for free boronic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-44e679c837df469fafa7034c812a6dcb |
| Source note | uspto-grants-2009_09 |