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HRID735550

反应详情

EQUATION

反应方程式

HRID 735550 的结构方程式

REACTANTS

反应物

2
结构：N#Cc1cccc(N=C=O)c1
HCID2733315

3-Cyanophenyl isocyanate

C8H4N2O

结构：CNCCCc1ccc(Br)cc1
HCID28350540

4-Bromo-N-methylbenzenepropanamine

C10H14BrN

PRODUCTS

生成物

1
结构：CN(CCCc1ccc(Br)cc1)C(=O)Nc1cccc(C#N)c1
HCID57842621

未命名化合物

收率 88%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

3-Isocyanatobenzonitrile (202 mg, 1.4 mmol) was added in one portion to a solution of 22B (320 mg, 1.4 mmol) in methylene chloride (10 mL). After stirring overnight the reaction mixture was concentrated in vacuo and purified by flash chromatography (0 to 100% EtOAc in hexanes) to yield 22C (430 mg, 88%) as a clear oil. MS (ESI) m/z 371.92/373.92 (M+H)+.

WORKUP

后处理

  1. concentrationwas concentrated in vacuo
  2. custompurified by flash chromatography (0 to 100% EtOAc in hexanes)