HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isocyanatobenzonitrile → 1-(3-(4-Bromophenyl)propyl)-3-(3-cyanophenyl)-1-methylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isocyanatobenzonitrile | HCID 2733315 | — |
| Reactant | 3-(4-Bromophenyl)-N-methylpropan-1-amine | HCID 28350540 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(3-(4-Bromophenyl)propyl)-3-(3-cyanophenyl)-1-methylurea | HCID 57842621 | 88% |
Reaction Steps
3-Isocyanatobenzonitrile (202 mg, 1.4 mmol) was added in one portion to a solution of 22B (320 mg, 1.4 mmol) in methylene chloride (10 mL). After stirring overnight the reaction mixture was concentrated in vacuo and purified by flash chromatography (0 to 100% EtOAc in hexanes) to yield 22C (430 mg, 88%) as a clear oil. MS (ESI) m/z 371.92/373.92 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-bc80ec3dbb094c8c893bcaaad977f63b |
| Source note | uspto-grants-2009_09 |