HRID735562

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCS(=O)(=O)c1ccc(NC(=O)N(C)CCc2ccc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc4c3)C(=O)O)cc2)cc1C#N

HCID57842902

未命名化合物

PRODUCTS

生成物

HCID57842775

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID935

Nickel

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of 25D (460 mg, 0.59 mmol) in MeOH (50 mL) with catalytic Raney Ni was stirred under an atmosphere of H2 (70 psi) for 20 h. The reaction mixture was filtered through Celite and concentrated to give 25E (340 mg, 73%) as a yellow oil. MS (ESI) m/z 790.95 (M+H)+.

WORKUP

后处理

filtrationThe reaction mixture was filtered through Celite
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f99dc189eb04cf0bf9244b1e5e57af3
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

[C:1]([O:5][C:6]([N:8]([C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])[C:9]1[C:18]2[C:13](=[CH:14][C:15]([NH:19][CH:20]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][N:32]([CH3:49])[C:33]([NH:35][C:36]4[CH:41]=[CH:40][C:39]([S:42]([CH2:45][CH3:46])(=[O:44])=[O:43])=[C:38]([C:47]#[N:48])[CH:37]=4)=[O:34])=[CH:26][CH:25]=3)[C:21]([OH:23])=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[NH2:48][CH2:47][C:38]1[CH:37]=[C:36]([NH:35][C:33](=[O:34])[N:32]([CH2:31][CH2:30][C:27]2[CH:28]=[CH:29][C:24]([CH:20]([NH:19][C:15]3[CH:14]=[C:13]4[C:18](=[CH:17][CH:16]=3)[C:9]([N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[C:50]([O:52][C:53]([CH3:54])([CH3:55])[CH3:56])=[O:51])=[N:10][CH:11]=[CH:12]4)[C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)[CH3:49])[CH:41]=[CH:40][C:39]=1[S:42]([CH2:45][CH3:46])(=[O:44])=[O:43]