HCID 57842780, compound → HCID 57842589, compound

HRID 735572Notes

Reaction equation

HRID 735572 reaction equation
C(O[C:9]([N:11](C)[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31](=[O:33])[NH2:32])[CH:26]=2)[C:21]([OH:23])=[O:22])=[CH:16][CH:15]=1)=O)C1C=CC=CC=1>[Pd]>[C:31]([C:27]1[CH:26]=[C:25]([NH:24][CH:20]([C:17]2[CH:16]=[CH:15][C:14]([CH2:13][CH2:12][NH:11][CH3:9])=[CH:19][CH:18]=2)[C:21]([OH:23])=[O:22])[CH:30]=[CH:29][CH:28]=1)(=[O:33])[NH2:32]

Participants

3

Reactant 1

HCID 57842780HCID 57842780, compound

Product 1

HCID 57842589HCID 57842589, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 28E (265 mg, 0.39 mmol) and Pd/C (10%, 40 mg) was stirred under H2 (1 atm) for 15 h. The reaction was filtered through Celite and concentrated to yield 28F (126 mg, 99%) as a yellow oil. MS (ESI) m/z 328.29 (M+H)+.

Workup

  1. filtrationThe reaction was filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-40523e5dc0b44e14a78a7c7632463bba
Source dataset
uspto-grants-2009_09
Patent number
US07592331B2

Reaction notes

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