HRID735596

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)C[C@H](NC(=O)OCc1ccccc1)c1cccc(NC(=O)OCCc2ccc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc4c3)C(=O)O)cc2C)c1

HCID57842900

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C[C@H](N)c1cccc(NC(=O)OCCc2ccc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc4c3)C(=O)O)cc2C)c1

HCID57842643

未命名化合物

收率 89%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of 34F (670 mg, 0.96 mmol) in MeOH (60 mL) and HCl (2.5 mL, 1.0 M aqueous) and Pd/C (60 mg) was stirred under an atmosphere of H2 (60 psi) for 8 h. The solution was filtered and concentrated in vacuo to yield 34G (600 mg, 89%) as a yellow solid. MS (ESI) m/z 786.4 (M+H)+.

WORKUP

后处理

filtrationThe solution was filtered
concentrationconcentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-880cd3a03c354a2c90cc36c36d6c8273
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

C(OC([NH:11][C@H:12]([C:19]1[CH:20]=[C:21]([NH:25][C:26]([O:28][CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([CH:37]([NH:41][C:42]3[CH:43]=[C:44]4[C:49](=[CH:50][CH:51]=3)[C:48]([N:52]([C:60]([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[O:61])[C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])=[N:47][CH:46]=[CH:45]4)[C:38]([OH:40])=[O:39])=[CH:33][C:32]=2[CH3:67])=[O:27])[CH:22]=[CH:23][CH:24]=1)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=O)C1C=CC=CC=1>CO.Cl.[Pd]>[NH2:11][C@H:12]([C:19]1[CH:20]=[C:21]([NH:25][C:26]([O:28][CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([CH:37]([NH:41][C:42]3[CH:43]=[C:44]4[C:49](=[CH:50][CH:51]=3)[C:48]([N:52]([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[C:60]([O:62][C:63]([CH3:66])([CH3:64])[CH3:65])=[O:61])=[N:47][CH:46]=[CH:45]4)[C:38]([OH:40])=[O:39])=[CH:33][C:32]=2[CH3:67])=[O:27])[CH:22]=[CH:23][CH:24]=1)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]