HRID735616

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1645

3-Aminobenzamide

C7H8N2O

HCID15620607

Oxoacetic acid--water (1/1)

C2H4O4

结构：CCOC(=O)C[C@@H](NC(=O)OCc1ccccc1)c1cccc(NC(=O)OCCc2ccc(B(O)O)cc2C)c1

HCID57842846

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C[C@@H](NC(=O)OCc1ccccc1)c1cccc(NC(=O)OCCc2ccc(C(Nc3cccc(C(N)=O)c3)C(=O)O)cc2C)c1

HCID57842821

未命名化合物

收率 44%

PROCEDURE

实验过程

Using a procedure analogous to that used to prepare 2D, 39E (200 mg, 0.36 mmol) was reacted with 3-aminobenzamide and glyoxylic acid monohydrate to afford 41A (232 mg, 44%) as a brown oil. MS (ESI) m/z 697.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-28c791d9cd9f4cbd83388e284be6152b
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([C:19]1[CH:20]=[C:21]([NH:25][C:26]([O:28][CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][C:32]=2[CH3:40])=[O:27])[CH:22]=[CH:23][CH:24]=1)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:41][C:42]1[CH:43]=[C:44]([CH:48]=[CH:49][CH:50]=1)[C:45]([NH2:47])=[O:46].O.[C:52]([OH:56])(=[O:55])[CH:53]=O>>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([C:19]1[CH:20]=[C:21]([NH:25][C:26]([O:28][CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([CH:53]([NH:41][C:42]3[CH:50]=[CH:49][CH:48]=[C:44]([C:45](=[O:46])[NH2:47])[CH:43]=3)[C:52]([OH:56])=[O:55])=[CH:33][C:32]=2[CH3:40])=[O:27])[CH:22]=[CH:23][CH:24]=1)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1