HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminobenzamide → 2-(4-(2-(3-((R)-1-(benzyloxycarbonylamino)-3-ethoxy-3-oxopropyl)phenylcarbamoyloxy)ethyl)-3-methylphenyl)-2-(3-carbamoylphenylamino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminobenzamide | HCID 1645 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | (R)-4-(2-(3-(1-(benzyloxycarbonylamino)-3-ethoxy-3-oxopropyl)phenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid | HCID 57842846 | — |
| Product | 2-(4-(2-(3-((R)-1-(benzyloxycarbonylamino)-3-ethoxy-3-oxopropyl)phenylcarbamoyloxy)ethyl)-3-methylphenyl)-2-(3-carbamoylphenylamino)acetic acid | HCID 57842821 | 44% |
Reaction Steps
Using a procedure analogous to that used to prepare 2D, 39E (200 mg, 0.36 mmol) was reacted with 3-aminobenzamide and glyoxylic acid monohydrate to afford 41A (232 mg, 44%) as a brown oil. MS (ESI) m/z 697.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-28c791d9cd9f4cbd83388e284be6152b |
| Source note | uspto-grants-2009_09 |