HCID 57842704, compound → 4-(2-(3-((Tert-butoxycarbonylamino)methyl)phenylcarbamoyloxy)ethyl)-3-chlorophenylbromide

HRID 735658Notes

Reaction equation

HRID 735658 reaction equation
C(OC(N[C@H](C1C=CC=C(NC(OCCC2C=CC(Br)=CC=2C)=O)C=1)CC(OCC)=O)=O)C1C=CC=CC=1.[N:39]([C:42]1[CH:43]=[C:44]([CH:54]=[CH:55][CH:56]=1)[CH2:45][NH:46][C:47](=[O:53])[O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=[C:40]=[O:41].[Br:57][C:58]1[CH:63]=[CH:62][C:61]([CH2:64][CH2:65][OH:66])=[C:60]([Cl:67])[CH:59]=1>>[C:49]([O:48][C:47]([NH:46][CH2:45][C:44]1[CH:43]=[C:42]([NH:39][C:40]([O:66][CH2:65][CH2:64][C:61]2[CH:62]=[CH:63][C:58]([Br:57])=[CH:59][C:60]=2[Cl:67])=[O:41])[CH:56]=[CH:55][CH:54]=1)=[O:53])([CH3:51])([CH3:52])[CH3:50]

Participants

4

Reactant 3

HCID 57842704HCID 57842704, compoundHCID 578428022-(4-Bromo-2-chlorophenyl)ethan-1-olHCID 83382972Tert-butyl 3-isocyanatobenzylcarbamate

Product 1

HCID 578425534-(2-(3-((Tert-butoxycarbonylamino)methyl)phenylcarbamoyloxy)ethyl)-3-chlorophenylbromideYield 50%

Procedure

Using a procedure analogous to that used to prepare 34D, 61C (1.94 g, 8.73 mmol) was reacted with 61B to give 61D (1.84 g, 50%) as an oil. MS (ESI) m/z 385.1 (M+H)+.

Sources & evidence

ORD record
ord-9e478959c7b44657a75039201bd966c5
Source dataset
uspto-grants-2009_09
Patent number
US07592331B2

Reaction notes

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