反应详情

To a round bottom flask contained EtMgCl (10 mL, 2M in THF, 20 mmol) at 0° C., was added a solution of 70A (516 mg, 2 mmol) in 10 mL THF. The solution was stirred at rt for 30 min, then was quenched with sat. NH4Cl and extracted with EtOAc (3×20 mL). The organic layer washed with brine, dried (Na2SO4) and concentrated. Purification via flash chromatography (0-30% EtOAc/hexanes) afforded 70B (288 mg, 65%). MS (ESI) m/z 227.1 (M+H)+.

1. customTo a round bottom flask contained
2. customwas quenched with sat. NH4Cl
3. extractionextracted with EtOAc (3×20 mL)
4. washThe organic layer washed with brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customPurification via flash chromatography (0-30% EtOAc/hexanes)