4-Bromo-beta,beta-dimethylbenzeneethanol → (2-(4-Bromophenyl)-2-methylpropoxy)(tert-butyl)dimethylsilane

HRID 735691Notes

Reaction equation

HRID 735691 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:18])[CH2:9][O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])=[CH:4][CH:3]=1.Br[C:20]1C=CC(C(C)(C)CO)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:20])([CH3:18])[CH2:9][O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 128051244-Bromo-beta,beta-dimethylbenzeneethanolHCID 57842594(2-(4-Bromophenyl)propoxy)(tert-butyl)dimethylsilane

Product 1

HCID 21986021(2-(4-Bromophenyl)-2-methylpropoxy)(tert-butyl)dimethylsilane

Procedure

According to the procedure for the preparation of 73C, 74A (1.93 g, 8.42 mmol) afforded 3.04 g of 74B as a colorless oil. MS (ESI) m/z 211.1 (M-OTBS)+.

Sources & evidence

ORD record
ord-2d7e1408c35a4f0a98f257de251af046
Source dataset
uspto-grants-2009_09
Patent number
US07592331B2

Reaction notes

Loading…