1-(4-Bromophenyl)propan-2-ol → (1-(4-Bromophenyl)propan-2-yloxy)(tert-butyl)dimethylsilane

HRID 735701Notes

Reaction equation

HRID 735701 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C)[CH2:9][O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])=[CH:4][CH:3]=1.Br[C:20]1C=CC(CC(O)C)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([O:10][Si:11]([C:14]([CH3:15])([CH3:16])[CH3:17])([CH3:12])[CH3:13])[CH3:20])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 198829011-(4-Bromophenyl)propan-2-olHCID 57842594(2-(4-Bromophenyl)propoxy)(tert-butyl)dimethylsilane

Product 1

HCID 57842700(1-(4-Bromophenyl)propan-2-yloxy)(tert-butyl)dimethylsilaneYield 87%

Procedure

According to the procedure for the preparation of 73C, 77A (4.90 g, 22.8 mmol) afforded 6.51 g (87%) of 77B as a colorless oil. MS (ESI) m/z 197.1 (M-OTBS)+.

Sources & evidence

ORD record
ord-01eb1626c1574e15a6d8f69e5abc13ac
Source dataset
uspto-grants-2009_09
Patent number
US07592331B2

Reaction notes

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