反应详情

To a solution of 79A (100 mg, 0.386 mmol) and 28A (148 mg, 0.386 mmol) in 2 mL pyridine at −15° C., was added POCl3 (0.040 mL, 0.425 mmol), dropwise. The mixture was stirred at this temperature for 20 min, then was quenched with water. The mixture was diluted with EtOAc, washed with water (2×), 1N HCl, water, sat. NaHCO3 and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography to afford 222 mg (98%) of 79B as a colorless oil. MS (ESI) m/z 589.2 (M+H)+.

1. customwas quenched with water
2. additionThe mixture was diluted with EtOAc
3. washwashed with water (2×), 1N HCl, water, sat. NaHCO3 and brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customThe crude product was purified by flash chromatography