反应详情

温度

0 °C

To a cold (0° C.) solution of tert-butyl 4-(trifluoromethyl)benzyl[4-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]carbamate (43 mg, 0.07 mmol) in DCM (3 mL) was added a solution of HCl (4N in dioxane, 3 mL) and the resulting reaction mixture was stirred 3 h at 0° C., then 14 h at rt. Evaporation of the solvent gave the title compound as a white powder used in the next steps without further purification (29 mg, 99%). M−(APCI): 486.0; M+(APCI): 488.2 HPLC (Condition A), Rt: 5.4 min (HPLC purity: 82%).

1. customthe resulting reaction mixture
2. custom14 h
3. customat rt
4. customEvaporation of the solvent