Water → HCID 67186359, compound

Temperature

0 °C

A solution of 4-bromobenzaldehyde (5.81 g, 31.4 mmol) and 4-(trifluoromethyl)-benzylamine (5.00 g, 28.6 mmol) in toluene (100 mL) was heated at reflux for 75 min with azeotropic removal of water. The toluene was evaporated off under reduce pressure. The residue was taken up in methanol (100 mL) and cooled to 0° C. NaBH4 (2.16 g, 57.1 mmol) was added portionwise and the reaction mixture was stirred at 0° C. for 1.5 h. The reaction mixture was poured into water (200 mL)/brine (200 mL) and extracted with Et2O (500 mL and 200 mL). The organic layers were washed with brine, combined and dried over MgSO4. The solvent was removed under reduce pressure. The residue was diluted with Et2O (200 mL) and HCl (1N in Et2O, 40 mL) was added. A white solid precipitated out. Filtration, washing with Et2O (3×20 mL) and drying under vacuum at 50° C. for 18 hrs gave the title compound as a white solid (9.74 g, 89%). 1H NMR (DMSO-d6, 300 MHz) δ 9.77 (s, 2H), 7.82 (d, 2H, J=8.5 Hz), 7.76 (d, 2H, J=8.5 Hz), 7.64 (d, 2H, J=8.3 Hz), 7.51 (d, 2H, J=8.3 Hz), 4.25 (s, 2H), 4.17 (s, 2H). M+(LC/MS(ESI)): 344.1. HPLC (Condition A), Rt: 3.16 min (HPLC purity: 99.7%).

1. customThe toluene was evaporated off
2. extractionextracted with Et2O (500 mL and 200 mL)
3. washThe organic layers were washed with brine
4. dry with materialdried over MgSO4
5. customThe solvent was removed
6. additionThe residue was diluted with Et2O (200 mL) and HCl (1N in Et2O, 40 mL)
7. additionwas added
8. customA white solid precipitated out
9. filtrationFiltration
10. washwashing with Et2O (3×20 mL)
11. customdrying under vacuum at 50° C. for 18 hrs

ORD record

ord-7ddd320cfb304eaf8904de03e33eea83

Source dataset

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07592477B2